Das Cabozantinib-Aminanalogon (CAS 190728-25-7) ist eine quinolinbasierte, prozessbedingte Verunreinigung mit der Struktur 6,7-Dimethoxy-4-(4-aminophenoxy)chinolin, entsprechend C17H16N2O3 und einer Molekülmasse von 296,32 g/mol. Es steht in enger Beziehung zum etherverknüpften Arylamin-Gerüst von Cabozantinib und kann durch unvollständige Kupplung, Debenzylierung oder hydrolytische Spaltung während der Synthese oder Lagerung entstehen. Als primäres Anilinderivat ist es kein Nitrosamin, doch die aromatische Aminofunktion erfordert eine Kontrolle gemäß ICH Q3A und, soweit relevant, ICH M7. Die Bestimmung erfolgt typischerweise mittels LC-MS/MS, LC-HRMS und orthogonaler HPLC-UV-Methoden; GC-MS ist aufgrund der Polarität meist weniger geeignet.
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