Apixaban Related Compound F, CAS 536759-91-8, ist Ethyl 1-(4-methoxyphenyl)-6-(4-nitrophenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate, eine substituierte Pyrazolopyridinon-Verunreinigung mit der Summenformel C22H20N4O6 und einer molaren Masse von 436,42 g/mol. Die Struktur weist einen nitroaromatischen Arylrest und einen veresterten heterozyklischen Kern auf, was auf ein prozessbedingtes Synthesezwischenprodukt oder Nebenprodukt bei der Bildung des Apixaban-Gerüsts hindeutet. Aufgrund möglicher genotoxischer Relevanz nitroaromatischer Verunreinigungen im Sinne von ICH M7 erfolgt die Spurendetektion üblicherweise mittels LC-MS/MS, hochauflösender Massenspektrometrie und orthogonaler HPLC-Methoden, da UV-basierte Verfahren häufig keine ausreichende Spezifität liefern.
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