Amikacin EP Impurity C, CAS 50725-25-2, ist eine definierte prozessbedingte Verunreinigung aus dem Aminoglykosid-Kontext und steht strukturell mit dem Amikacin-Gerüst in Zusammenhang, wobei sie eine Abweichung innerhalb des Aminocyclitol-Glycosid-Scaffolds darstellt. Mit der Summenformel C22H43N5O13 und einer Molmasse von 585,60 g/mol behält sie den stark hydroxilierten, polykationischen Charakter dieser Substanzklasse bei. Solche Spezies können bei semisynthetischer Glykosylierung, selektiver Entschützung oder hydrolytischer Umwandlung geschützter Vorstufen entstehen. Aufgrund ähnlicher chromatographischer Eigenschaften und schwacher UV-Absorption werden zur Identifizierung LC-MS/MS, hochauflösende LC-MS und HILIC eingesetzt, ergänzt durch NMR.
References
Ramirez, Maria, and Marcelo Tolmasky. “Amikacin: Uses, Resistance, and Prospects for Inhibition.†Molecules, vol. 22, no. 12, Dec. 2017, p. 2267, https://doi.org/10.3390/molecules22122267 Wang, Jian, et al. “Separation and Characterization of Unknown Impurities in Amikacin Sulfate by HPLC–MS N.†Chromatographia, vol. 78, no. 15-16, May 2015, pp. 1031–39, https://doi.org/10.1007/s10337-015-2909-8.?
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