Avatrombopag Nitroso Impurity 2 ist eine strukturell definierte nitrosoverwandte Verunreinigung aus dem Prozess- oder Abbauprofil von Avatrombopag und gehört aufgrund der N-Nitroso-Funktionalität in den Bereich der Nitrosamin-Risiken. Mit der Summenformel C11H12ClN5OS2 und einer Molekülmasse von 329,83 g/mol weist die Verbindung ein chloriertes Heteroaromatensystem sowie Schwefelheteroatome auf, die Polarität, Ionisationsverhalten und chromatographische Retention beeinflussen. Solche Spezies werden im Rahmen von ICH M7 bewertet, da Nitrosoverbindungen potenziell genotoxisch sind. Für den Nachweis und die Gehaltsbestimmung sind typischerweise LC-MS/MS, hochauflösende LC-MS und, sofern flüchtigkeitsbedingt geeignet, GC-MS erforderlich.
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