Calcitriol EP Impurity B, auch 1β-Calcitriol oder 1-epi-Calcitriol genannt, ist ein stereoisomeres Vitamin-D3-Metabolit mit der Summenformel C27H44O3 und einer Molekülmasse von 416.64 g/mol, CAS 66791-71-7. Es unterscheidet sich von Calcitriol durch die Inversion an C1, wodurch die Hydroxylgruppe in β-Orientierung vorliegt und sich Rezeptorerkennung sowie Stoffwechselverhalten ändern. Die Verunreinigung entsteht typischerweise durch Epimerisierung während der Synthese oder Lagerung von Secosteroid-Substanzen. Da die Identifizierung die Trennung eng verwandter Epimere erfordert, erfolgt die Charakterisierung meist mittels LC-MS/MS, hochauflösender Massenspektrometrie sowie chiraler oder RP-HPLC mit NMR-Stützung.
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