D-Glu(4)-Teriparatid ist eine oxidativ deamidierte Peptidverunreinigung von Teriparatid, bei der der native Asn4-Rest durch D-Glutaminsäure ersetzt ist. Dadurch entsteht eine diastereomere Sequenzvariante mit veränderter Ladungsverteilung und Konformation. Solche Spezies können während der Peptidsynthese, durch Racemisierung oder als stressbedingte Nebenprodukte über Asn-Deamidierung und Epimerisierung entstehen. Da hier keine Summenformel und kein Molekulargewicht angegeben sind, stützt sich die Charakterisierung auf LC-MS der intakten Masse, Peptid-Mapping mittels LC-MS/MS sowie orthogonale RP-HPLC oder Kapillarelektrophorese. Die Bewertung erfolgt im Rahmen der Verunreinigungskontrolle peptidischer Wirkstoffe mit Fokus auf Strukturaufklärung und limitbasierter Spezifikation.
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To provide the best experiences, we use technologies like cookies to store and/or access device information. Consenting to these technologies will allow us to process data such as browsing behavior or unique IDs on this site. Not consenting or withdrawing consent, may adversely affect certain features and functions.
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The technical storage or access is strictly necessary for the legitimate purpose of enabling the use of a specific service explicitly requested by the subscriber or user, or for the sole purpose of carrying out the transmission of a communication over an electronic communications network.
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