D-His(32)-Teriparatid ist eine sequenzvarianten Peptidverunreinigung des Parathormon-Analogons Teriparatid, gekennzeichnet durch den Austausch des natürlich konfigurierte Histidins an Position 32 gegen das D-Enantiomer. Dieses stereochemische Epimer steht typischerweise im Zusammenhang mit Racemisierung während der Peptidsynthese oder mit alkalischer Exposition während Herstellung und Lagerung. Als nichtkanonische Peptidverunreinigung kann es das Rezeptorbindungsverhalten und die biologische Potenz beeinflussen. Die Charakterisierung erfordert in der Regel LC-MS/MS mit hochauflösender exakter Massenbestimmung, Peptid-Mapping und orthogonale Verunreinigungsprofile mittels RP-HPLC. Es sind hier keine validierten Angaben zu CAS, Summenformel oder Molekulargewicht zugeordnet.
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