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2187409-01-2Des(2-oxo-1-piperidinyl) 6-(4-(5-Amino-5-oxopentyl)) Apixaban

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Katalog-Nr.::	VE009573
CAS-Nr.::	2187409-01-2
Summenformel::	C25H28N6O4
Molare Masse::	476.53 g/mol

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Zusätzliche Informationen zu CAS 2187409-01-2

Parent drug

Apixaban

IUPAC-Name

6-[4-[(5-Amino-5-oxopentyl)amino]phenyl]-4, 5, 6, 7-tetrahydro-1-(4-methoxyphenyl)-7-oxo-1H-Pyrazolo[3, 4-c]pyridine-3-carboxamide

Pharmakopöe-Synonyme

Apixaban Open Ring Amide

Other Synonyms

Apixaban Open Chain Amide

SMILES

COC1=CC=C(C=C1)N2C3=C(CCN(C3=O)C4=CC=C(C=C4)NCCCCC(=O)N)C(=N2)C(=O)N

InChI

InChI=1S/C25H28N6O4/c1-35-19-11-9-18(10-12-19)31-23-20(22(29-31)24(27)33)13-15-30(25(23)34)17-7-5-16(6-8-17)28-14-3-2-4-21(26)32/h5-12,28H,2-4,13-15H2,1H3,(H2,26,32)(H2,27,33)

Beschreibung

Des(2-oxo-1-piperidinyl) 6-(4-(5-Amino-5-oxopentyl)) Apixaban, also known as Apixaban Open Ring Amide in various pharmacopoeias, is a highly characterized standard. It meets strict regulatory requirements set by USP, EMA, JP, and BP, making it a crucial component in Abbreviated New Drug Applications (ANDA), New Drug Applications (NDA), and the commercial production of Apixaban.

References

WONG, P. C., et al. â€œApixaban, an Oral, Direct and Highly Selective Factor Xa Inhibitor: In Vitro, Antithrombotic and Antihemostatic Studies.â€ Journal of Thrombosis and Haemostasis, vol. 6, no. 5, May 2008, pp. 820â€“29, https://doi.org/10.1111/j.1538-7836.2008.02939.x. Accessed 15 Apr. 2023.