Ethylarachidat, auch Ethylicosanoat genannt, CAS 18281-05-5, ist der Ethylester der Arachinsäure und ein langkettiger gesättigter Fettsäureester mit der Formel C22H44O2 und einer Molekülmasse von 340,58 g/mol. In der Verunreinigungscharakterisierung pharmazeutischer Stoffe wird es überwiegend als prozessbedingtes Esterifizierungsnebenprodukt oder als lipidgebundener Fremdstoff bewertet, nicht als reaktive mutagene Spezies. Seine geringe Polarität und hohe Hydrophobizität begünstigen die Retention auf Umkehrphasen. Die eindeutige Identifizierung erfolgt typischerweise mittels GC-MS, GC-FID oder LC-MS/MS nach geeigneter chromatographischer Trennung. Für die Gehaltsbestimmung können erhöhte Temperaturen oder Derivatisierung erforderlich sein.
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