Ethylcyanoacetat, CAS 105-56-6, ist der Ethylester der Cyanoessigsäure und ein reaktives Cyanoester-Zwischenprodukt mit der Formel C5H7NO2 und einer Molekülmasse von 113,11 g/mol. In Verunreinigungsprofilen kann es aus Veresterungs- oder Umesterungsreaktionen entstehen und als prozessbedingter Rest in Synthesewegen mit aktivierten Methylenverbindungen verbleiben. Nitril- und Esterfunktion bestimmen Polarität und Fragmentierung, weshalb LC-MS/MS und GC-MS für Spurenidentifikation und Quantifizierung bevorzugt werden. Aufgrund der Reaktivität cyanofunktioneller Spezies wird es im Rahmen von Verunreinigungskontrollstrategien toxikologisch bewertet.
References
“Solvent-Free Microwave Enhanced Knoevenagel Condensation of Ethyl Cyanoacetate with Aldehydes.†Synthetic Communications, 2021, www.tandfonline.com/doi/abs/10.1080/00397919908086438. “Solvent-Free Synthesis of Ethyl a-Cyanocinnamate in the Presence of CaO.†Synthetic Communications, 2021, www.tandfonline.com/doi/abs/10.1081/SCC-120037918?journalCode=lsyc20. ?
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