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1260832-79-8Fostamatinib-D6

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Katalog-Nr.::	DVE002151
CAS-Nr.::	1260832-79-8
Summenformel::	C23H20D6FN6O9P
Molare Masse::	586.50 g/mol

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Zusätzliche Informationen zu CAS 1260832-79-8

Parent drug

Fostamatinib

IUPAC-Name

(6-((5-fluoro-2-((3,4,5-trimethoxyphenyl)amino)pyrimidin-4-yl)amino)-2,2-bis(methyl-d3)-3-oxo-2,3-dihydro-4H-pyrido[3,2-b][1,4]oxazin-4-yl)methyl dihydrogen phosphate

Pharmacopeial Synonyms

N/A

Synonyme

N/A

SMILES

COC1=CC(NC2=NC=C(F)C(NC3=CC=C(OC(C([2H])([2H])[2H])(C4=O)C([2H])([2H])[2H])C(N4COP(O)(O)=O)=N3)=N2)=CC(OC)=C1OC

InChI

InChI=1S/C23H26FN6O9P/c1-23(2)21(31)30(11-38-40(32,33)34)20-14(39-23)6-7-17(28-20)27-19-13(24)10-25-22(29-19)26-12-8-15(35-3)18(37-5)16(9-12)36-4/h6-10H,11H2,1-5H3,(H2,32,33,34)(H2,25,26,27,28,29)/i1D3,2D3

Beschreibung

Fostamatinib-D6 (CAS 1260832-79-8) is a deuterium-labeled impurity of fostamatinib characterized by six incorporated deuterons, producing a predictable +6 Da mass shift that aids unambiguous mass spectrometric discrimination from the parent molecule. This impurity exhibits distinct isotopic cluster patterns, retention time shifts in reversed-phase LC, and reproducible 1H and 2H NMR signatures that facilitate structural confirmation and impurity profiling. Relevant for stability studies and forced-degradation assessments, Fostamatinib-D6 supports trace-level quantitation, method validation and peak assignment under ICH impurity guidance by providing a robust analytical marker with high chemical purity and defined isotopic enrichment.