N-Nitroso-2-pyrrolidon, CAS 54634-49-0, ist ein cyclisches N-Nitrosamin mit der Summenformel C4H6N2O2 und einer Molekülmasse von 114,1 g/mol. Die Verbindung ist strukturell mit 2-Pyrrolidon verwandt und kann bei der Nitrosierung des entsprechenden Lactams unter sauren Bedingungen in Gegenwart von Nitrit oder anderen nitrosierenden Spezies entstehen. Als Vertreter der Nitrosamine wird sie im Rahmen von ICH M7 als potenzielle genotoxische Verunreinigung bewertet. Die Bestimmung im Spurenbereich erfordert in der Regel hochselektive LC-MS/MS- oder GC-MS-Verfahren, häufig mit isotopenmarkierten internen Standards, um die erforderliche Empfindlichkeit und Selektivität zu erreichen.
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