Palonosetron EP Impurity C ist die chirale Amidverunreinigung (S)-N-((S)-quinuclidin-3-yl)-1,2,3,4-tetrahydronaphthalin-1-carboxamid, eine nichtflüchtige, basische stickstoffhaltige verwandte Substanz mit der Summenformel C18H24N2O und einer Molmasse von 284,40 g/mol. Die Struktur weist auf den Erhalt des Tetrahydronaphthalin-Amidgerüsts sowie eines Quinuclidin-Stereozentrums hin, was mit einem Syntheseintermediat oder einem während Kopplungs- oder Epimerisierungsschritten entstehenden Stereoisomer vereinbar ist. Da es sich nicht um ein Nitrosamin oder einen klassischen DNA-reaktiven Spurenstoff handelt, liegt der regulatorische Fokus auf dem Verunreinigungsprofil und nicht auf einer ICH-M7-Klassifizierung. Der Nachweis erfolgt typischerweise mittels RP-LC mit UV und Bestätigung durch LC-MS/MS sowie orthogonaler Charakterisierung durch NMR oder hochauflösende Massenspektrometrie.
To provide the best experiences, we use technologies like cookies to store and/or access device information. Consenting to these technologies will allow us to process data such as browsing behavior or unique IDs on this site. Not consenting or withdrawing consent, may adversely affect certain features and functions.
Functional
Immer aktiv
The technical storage or access is strictly necessary for the legitimate purpose of enabling the use of a specific service explicitly requested by the subscriber or user, or for the sole purpose of carrying out the transmission of a communication over an electronic communications network.
Preferences
The technical storage or access is necessary for the legitimate purpose of storing preferences that are not requested by the subscriber or user.
Statistics
The technical storage or access that is used exclusively for statistical purposes.The technical storage or access that is used exclusively for anonymous statistical purposes. Without a subpoena, voluntary compliance on the part of your Internet Service Provider, or additional records from a third party, information stored or retrieved for this purpose alone cannot usually be used to identify you.
Marketing
The technical storage or access is required to create user profiles to send advertising, or to track the user on a website or across several websites for similar marketing purposes.
To provide the best experiences, we use technologies like cookies to store and/or access device information. Consenting to these technologies will allow us to process data such as browsing behavior or unique IDs on this site. Not consenting or withdrawing consent, may adversely affect certain features and functions.
Functional
Immer aktiv
The technical storage or access is strictly necessary for the legitimate purpose of enabling the use of a specific service explicitly requested by the subscriber or user, or for the sole purpose of carrying out the transmission of a communication over an electronic communications network.
Preferences
The technical storage or access is necessary for the legitimate purpose of storing preferences that are not requested by the subscriber or user.
Statistics
The technical storage or access that is used exclusively for statistical purposes.The technical storage or access that is used exclusively for anonymous statistical purposes. Without a subpoena, voluntary compliance on the part of your Internet Service Provider, or additional records from a third party, information stored or retrieved for this purpose alone cannot usually be used to identify you.
Marketing
The technical storage or access is required to create user profiles to send advertising, or to track the user on a website or across several websites for similar marketing purposes.
![N-[(S)-1-Azabicyclo[2,2,2]oct-3-yl]-5,6,7,8-tetrahydro-1-naphthelene carboxamide](https://veeprho.com/wp-content/uploads/2022/07/N-5BS-1-Azabicyclo5B2-2-25Doct-3-yl5D-5-6-7-8-tetrahydro-1-naphthelene-carboxamide.png "N-[(S)-1-Azabicyclo[2,2,2]oct-3-yl]-5,6,7,8-tetrahydro-1-naphthelene carboxamide")