100 % Datengenauigkeit
Wissenschaftlicher Support rund um die Uhr
0 % Toleranz bei der Produktqualität
Lagerstandorte
- New Jersey, USA
- Czech Republic, EU
- Mumbai, India
* Vorbehaltlich Verfügbarkeit
Dokumentation
Enthält: HPLC, MASS/LC-MS, 1H-NMR, FT-IR, Gehalt, Structure Elucidation Report (SER) sowie zusätzliche analytische Daten je nach Produkt.
Relebactam-D4
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| Katalog-Nr.:: | DVE002148 |
|---|---|
| CAS-Nr.:: | N/A |
| Summenformel:: | C12H16D4N4O6S |
| Molare Masse:: | 352.40 g/mol |
Zusätzliche Informationen zu
Parent drug
RelebactamIUPAC-Name
(1R,2S,5R)-7-oxo-2-((piperidin-4-yl-3,3,5,5-d4)carbamoyl)-1,6-diazabicyclo[3.2.1]octan-6-yl hydrogen sulfatePharmacopeial Synonyms
N/ASynonyme
N/ASMILES
[2H]C1([2H])CNCC([2H])([2H])C1NC(C2CC[C@H]3N(OS(O)(=O)=O)C([N@@]2C3)=O)=OInChI
InChI=1S/C12H20N4O6S/c17-11(14-8-3-5-13-6-4-8)10-2-1-9-7-15(10)12(18)16(9)22-23(19,20)21/h8-10,13H,1-7H2,(H,14,17)(H,19,20,21)/t9-,10?/m1/s1/i3D2,4D2Beschreibung
Relebactam-D4 impurity is a deuterated process-related byproduct encountered during synthesis and stability studies of relebactam. Characterization requires high-resolution LC-MS and quantitative 1H and 2H NMR to confirm isotopic incorporation and residual undeuterated species. This impurity impacts assay accuracy and can co-elute with polar intermediates, complicating chromatographic resolution. Forced-degradation experiments identify hydrolytic and oxidative pathways that generate Relebactam-D4, informing specification limits and control strategy. Robust method development includes orthogonal HPLC with ion-pairing or HILIC, MS/MS fragmentation profiling, and validated stability-indicating assays to ensure detection at low ppm levels. Understanding its physicochemical properties guides purification and regulatory reporting.Angebot anfordern
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Verunreinigungsstruktur
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