Sacubitril-(2S,4S)-Isomer, auch als Sacubitril-2-Epimer bezeichnet, CAS 149709-63-7, ist eine stereoisomere, prozessbedingte Verunreinigung des Neprilysin-Inhibitors Sacubitril und kein eigenständiges strukturelles Abbauprodukt. Die Summenformel C24H29NO5 und die Molmasse von 411,49 g/mol kennzeichnen die epimerisierte stereochemische Variante, die bei unvollständiger stereochemischer Kontrolle in der Synthese oder Aufarbeitung entstehen kann. Aufgrund der engen strukturellen Nähe zum Wirkstoff erfordert die Spurendetektion typischerweise chirale HPLC mit orthogonaler Bestätigung durch LC-MS/MS und gegebenenfalls NMR. Die regulatorische Bewertung betrifft Spezifikationen, stereochemische Reinheit und die Kontrolle der Epimerbildung nach den Grundsätzen von ICH Q3A und Q3B.
To provide the best experiences, we use technologies like cookies to store and/or access device information. Consenting to these technologies will allow us to process data such as browsing behavior or unique IDs on this site. Not consenting or withdrawing consent, may adversely affect certain features and functions.
Functional
Immer aktiv
The technical storage or access is strictly necessary for the legitimate purpose of enabling the use of a specific service explicitly requested by the subscriber or user, or for the sole purpose of carrying out the transmission of a communication over an electronic communications network.
Preferences
The technical storage or access is necessary for the legitimate purpose of storing preferences that are not requested by the subscriber or user.
Statistics
The technical storage or access that is used exclusively for statistical purposes.The technical storage or access that is used exclusively for anonymous statistical purposes. Without a subpoena, voluntary compliance on the part of your Internet Service Provider, or additional records from a third party, information stored or retrieved for this purpose alone cannot usually be used to identify you.
Marketing
The technical storage or access is required to create user profiles to send advertising, or to track the user on a website or across several websites for similar marketing purposes.
To provide the best experiences, we use technologies like cookies to store and/or access device information. Consenting to these technologies will allow us to process data such as browsing behavior or unique IDs on this site. Not consenting or withdrawing consent, may adversely affect certain features and functions.
Functional
Immer aktiv
The technical storage or access is strictly necessary for the legitimate purpose of enabling the use of a specific service explicitly requested by the subscriber or user, or for the sole purpose of carrying out the transmission of a communication over an electronic communications network.
Preferences
The technical storage or access is necessary for the legitimate purpose of storing preferences that are not requested by the subscriber or user.
Statistics
The technical storage or access that is used exclusively for statistical purposes.The technical storage or access that is used exclusively for anonymous statistical purposes. Without a subpoena, voluntary compliance on the part of your Internet Service Provider, or additional records from a third party, information stored or retrieved for this purpose alone cannot usually be used to identify you.
Marketing
The technical storage or access is required to create user profiles to send advertising, or to track the user on a website or across several websites for similar marketing purposes.
![(2S,4R)-5-([1,1'-Biphenyl]-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic Acid](https://veeprho.com/wp-content/uploads/2023/03/2S-4R-5-1-1-Biphenyl-4-yl-4-tert-butoxycarbonyl-amino-2-methylpentanoic-Acid.png "(2S,4R)-5-([1,1'-Biphenyl]-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic Acid")
![(2R,4S)-5-(Biphenyl-4-yl)-4-[(tert-butoxycarbonyl)amino]-2-methylpentanoic Acid](https://veeprho.com/wp-content/uploads/2026/02/2R4S-5-Biphenyl-4-yl-4-tert-butoxycarbonylamino-2-methylpentanoic-Acid-1012341-50-2-VE009680-ac14.png "(2R,4S)-5-(Biphenyl-4-yl)-4-[(tert-butoxycarbonyl)amino]-2-methylpentanoic Acid")
![(2R,4S)-ethyl 5-([1,1'-biphenyl]-4-yl)-4-amino-2-methylpentanoate](https://veeprho.com/wp-content/uploads/2023/11/VE0016600-2R-4S-ethyl-5-1-1-biphenyl-4-yl-4-amino-2-methylpentanoate.png "(2R,4S)-ethyl 5-([1,1'-biphenyl]-4-yl)-4-amino-2-methylpentanoate")
