H-Cys-Ser(Ac)-Asn-Leu-Ser-Thr-Cys-Val-Leu-Gly-Lys-Leu-Ser-Gln-Glu-Leu-His-Lys-Leu-Gln-Thr-Tyr-Pro-Arg-Thr-Asn-Thr-Gly-Ser-Gly-Thr-Pro-NH2 (Disulfide formation between Cys1 and Cys7)
Pharmacopeial Synonyms
N/A
Synonyme
N/A
Beschreibung
Ser-2(Ac)-Calcitonin ist eine acetylierte, peptidbezogene Verunreinigung von Calcitonin, die durch eine ortsspezifische Modifikation des N-terminalen Serinrests entsteht und eher eine prozess- oder abbauassoziierte Variante als ein niedermolekulares Abbauprodukt darstellt. Mit der Summenformel C147H242N44O49S2 und einer Molekülmasse von 3473.93 g/mol erhält sie das disulfidverknüpfte Calcitonin-Gerüst und die für große therapeutische Peptide typische physikochemische Komplexität. Strukturaufklärung und Quantifizierung erfordern in der Regel LC-MS/MS mit hochauflösender MS, ergänzt durch Peptid-Mapping und chromatographische Trennung eng verwandter Analoga. Ihre Charakterisierung ist für das Verunreinigungsprofil relevant, da Acetylierung Rezeptorbindung, Stabilität und Ladungshomogenität beeinflussen kann.
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