Desmethoxy Aliskiren Impurity is formed by degradation of Aliskiren that is employed in the treatment of hypertension that acts by selectively inhibiting renin, the enzyme responsible for the conversion of angiotensinogen to angiotensin-I.
References
Kushwah, Bhoopendra Singh, et al. “Characterization of Solution Stress Degradation Products of Aliskiren and Prediction of Their Physicochemical and ADMET Properties.â€Â European Journal of Pharmaceutical Sciences, vol. 121, Aug. 2018, pp. 139–54, https://doi.org/10.1016/j.ejps.2018.05.021.
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