3′-Bromopropiofenona (CAS 19829-31-3) | conocida como impureza MBPP del bupropión | es una impureza bromada aromática que debe monitorizarse en perfiles de impurezas por su potencial impacto en la calidad del producto final. Presenta un núcleo cetona aromática con sustitución bromo y su detección y cuantificación se realizan mediante HPLC-UV | LC-MS y GC-MS | complementadas con espectroscopía NMR para confirmación estructural. Su control exige métodos analíticos validados y límites basados en ICH Q3A | además de condiciones de almacenamiento que minimicen degradación y formación posterior | facilitando la mitigación de riesgos regulatorios.
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