3-Deoxi-3-acetilabiraterona-3-eno (CAS 2697127-16-3) es una impureza esteroidea relacionada con el proceso del esqueleto de abiraterona, definida por la pérdida de la función 3-hidroxilo, acetilación en C-3 y una insaturación 3-eno. Su fórmula molecular, C26H31NO, y su peso molecular, 373.53 g/mol, corresponden a un derivado oxidado lipofílico con nitrógeno y no a un simple producto de degradación. Su formación se atribuye habitualmente a reacciones secundarias de síntesis durante etapas de protección, desprotección o transferencia de acilo. La asignación estructural y la cuantificación suelen requerir LC-MS/MS, con apoyo de HRMS y NMR en perfiles de impurezas.
Referencias
Goldberg, Tamara, and Evangelina Berrios-Colon. “Abiraterone (Zytiga), a Novel Agent for the Management of Castration-Resistant Prostate Cancer.†Pharmacy and Therapeutics, vol. 38, no. 1, 1 Jan. 2013, pp. 23–26, www.ncbi.nlm.nih.gov/pmc/articles/PMC3628169/. Accessed 31 Jan. 2022.
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