4-Cloro Bupropion Fumarato (CAS 1193779-36-0) es una impureza de síntesis que puede aparecer durante la cloración parcial o reacciones secundarias en la fabricación de bupropion. Su detección y cuantificación son críticas para garantizar perfiles de impurezas dentro de especificaciones regulatorias | utilizando técnicas analíticas como HPLC con detección UV | LC-MS para confirmación de masa y RMN para estructura. Se recomienda establecer límites de aceptación | métodos de muestreo validados y estudios de estabilidad para evaluar su formación y degradación. El control del proceso y la optimización de condiciones de reacción reducen la presencia de este compuesto y mejoran la pureza del producto final.
Referencias
“Bupropion (Wellbutrin), NAMI: National Alliance on Mental Illness.†Nami.org, 2021, www.nami.org/About-Mental-Illness/Treatments/Mental-Health-Medications/Types-of-Medication/Bupropion-(Wellbutrin)#:~:text=Bupropionisanantidepressantmedication, feelingsademptyortearful.
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