La impureza Amoxicillin trihydrate (CAS 61336-70-7) es una especie relacionada estructuralmente con la amoxicilina que aparece como trihidrato cristalino y contiene agua de cristalización | lo que influye en su comportamiento higroscópico y en la estabilidad del lote. Como impureza polar | presenta alta solubilidad en agua y perfiles de retención característicos en cromatografía líquida | detectables por UV y espectrometría de masas | y puede enmascarar o alterar la cuantificación del principio activo si no se controla. Su identificación exige métodos validados que evalúen pureza | contenido de agua y productos de degradación | así como condiciones de almacenamiento que minimicen su formación.
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