N,S-bis(Carboximetil)-L-cisteína, CAS 907565-13-3, es un derivado de aminoácido que contiene azufre con fórmula molecular C7H11NO6S y peso molecular de 237.23 g/mol. Desde el punto de vista estructural, corresponde a un aducto tioéter y amino-dicarboxílico generado por la carboximetilación de las funciones amino y tiol de la L-cisteína. Esta especie puede originarse como subproducto de síntesis o por sobrealquilación en procesos derivados de cisteína. Su carácter zwitteriónico y altamente polar dificulta la retención en fase reversa. La detección y cuantificación a nivel traza suelen requerir LC-MS/MS, a veces con cromatografía de pares iónicos, ya que la detección UV es limitada.
Referencias
Zeng, Z., Yang, D., Huang, X., & Xiao, Z. (2017). Effect of carbocisteine on patients with COPD: a systematic review and meta-analysis. International Journal of Chronic Obstructive Pulmonary Disease, Volume 12, 2277–2283. https://doi.org/10.2147/copd.s140603
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