Abacavir Cyclopropyl Diamino Purine Impurity (CAS 120503-69-7) | también denominada Cyclopropyldiaminopurine Abacavir o 2-Amino-6-cyclopropylaminopurine | es una impureza estructural relevante en procesos de síntesis y degradación del abacavir. Su identificación y cuantificación mediante HPLC con detección UV y espectrometría de masas | apoyadas por RMN 1H/13C | permiten caracterizar su masa molecular y patrones de fragmentación. Esta impureza puede originarse por reacciones de sustitución en la posición N6 o por condiciones de proceso no optimizadas | y requiere control según límites de especificación basados en ICH Q3A/Q3B para garantizar calidad y seguridad. Se recomienda seguimiento en perfiles de impurezas y estrategias de eliminación en etapas de purificación.
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