Ubicación del inventario
- New Jersey, USA
- Czech Republic, EU
- Mumbai, India
* Sujeto a disponibilidad
Documentation
Incluye: HPLC, MASS/LC-MS, RMN de 1H, FT-IR, potencia, informe de elucidación estructural (SER) y datos analíticos adicionales según el producto.
1231930-82-7Abemaciclib Mesylate
● Under Development
| Número de catálogo: | VL4990001 |
|---|---|
| N.º CAS: | 1231930-82-7 |
| Fórmula mol.:: | C₂₈H₃₆F₂N₈O₃S |
| Peso mol.:: | 602.7 g/mol |
Información adicional sobre el CAS 1231930-82-7
Fármaco de origen
AbemaciclibNombre IUPAC
N-[5-[(4-Ethyl-1-piperazinyl)methyl]-2-pyridinyl]-5-fluoro-4-[4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl]-2-pyrimidinamine MethanesulfonateSinónimos farmacopeicos
N/AOtros sinónimos
Abemaciclib Methanesulfonate; N-(5-((4-ethylpiperazin-1-yl)methyl)pyridin-2-yl)-5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-amine methanesulfonate; 2-Pyrimidinamine, N-(5-((4-ethyl-1-piperazinyl)methyl)-2-pyridinyl)-5-fluoro-4-(4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl)-, methanesulfonate (1:1); N-[5-[(4-ethylpiperazin-1-yl)methyl]pyridin-2-yl]-5-fluoro-4-(7-fluoro-2-methyl-3-propan-2-ylbenzimidazol-5-yl)pyrimidin-2-amine;methanesulfonic acid; Methanesulfonic acid–N-{5-[(4-ethylpiperazin-1-yl)methyl]pyridin-2-yl}-5-fluoro-4-[4-fluoro-2-methyl-1-(propan-2-yl)-1H-benzimidazol-6-yl]pyrimidin-2-amine (1/1)Descripción
Impureza de Abemaciclib Mesylate (CAS 1231930-82-7) caracterizada por especies relacionadas estructuralmente como desmetilados | isómeros posicionales | dessulfonatos | N-óxidos y subproductos procedentes del fragmento piperazínico; estas impurezas se generan durante la síntesis | la purificación o por degradación inducida por humedad | calor u oxidantes y requieren un perfil de impurezas robusto para garantizar la calidad del material. La identificación y cuantificación se realiza mediante HPLC con detección UV | LC-MS y NMR para establecer límites de aceptación. Su control incluye optimización de condiciones de reacción | etapas de lavado y cromatografía | estudios de estabilidad forzada y cumplimiento de guías ICH Q3A/Q3B para definir especificaciones analíticas.
Referencias
Kim, Esther S. “Abemaciclib: First Global Approval.” Drugs, vol. 77, no. 18, Nov. 2017, pp. 2063–70, https://doi.org/10.1007/s40265-017-0840-z.Solicitar cotización
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