Avatrombopag Nitroso Impurity 2 es una impureza nitroso estructuralmente definida asociada al perfil de proceso o degradación de avatrombopag, incluida en el ámbito de riesgo de las nitrosaminas por la funcionalidad N-nitroso implícita en su denominación. Con fórmula molecular C11H12ClN5OS2 y peso molecular de 329,83 g/mol, presenta un sistema heteroaromático clorado y átomos de azufre que modulan la polaridad, la ionización y el comportamiento cromatográfico. Estas especies se evalúan bajo consideraciones de ICH M7 debido a su posible genotoxicidad. Su detección y cuantificación suelen requerir LC-MS/MS, LC-MS de alta resolución y, cuando la volatilidad lo permite, GC-MS.
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