(6R, 13S, 25R)-22, 23-didehydro-5-O-demethyl-28-deoxy-6, 28-epoxy-13-hydroxy-25-[(1S)-1-methylpropyl]-milbemycin B
Sinónimos
N/A
Descripción
La Avermectina B1a aglicona (CAS 71828-14-3) se describe como una impureza relevante en el perfil de calidad de productos derivados de avermectinas. Presenta propiedades fisicoquímicas y rutas de degradación que requieren control analítico riguroso para evitar efectos sobre potencia y estabilidad. Métodos validados como HPLC con detección UV y LC-MS permiten cuantificación y caracterización estructural | mientras que estudios de solubilidad y reactividad clarifican su comportamiento en matrices formuladas. Establecer límites de aceptación | condiciones de almacenamiento y procedimientos de eliminación es esencial para cumplir requisitos regulatorios y asegurar trazabilidad en control de calidad durante desarrollo y producción.
Referencias
Hanessian, S., et al. “Progress in Natural Product Chemistry by the Chiron and Related Approaches – Synthesis of Avermectin B1a.â€Â Pure and Applied Chemistry, vol. 59, no. 3, Jan. 1987, pp. 299–316, https://doi.org/10.1351/pac198759030299.
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