Bupropion Propiophenone Impurity (CAS 93-55-0) | también conocida como 3-Phenyl-3-propanone | Ethyl Phenyl Ketone | Phenyl Ethyl Ketone o Propionylbenzene | es una cetona aromática identificada como impureza potencial en la síntesis y formulación de bupropion. Presenta propiedades lipofílicas y reactividad de carbonilo que pueden comprometer la pureza del principio activo y la estabilidad del lote. Su control analítico mediante HPLC | GC-MS y espectrometría de masas es esencial para el cumplimiento de límites según guías ICH y la evaluación de riesgos. La caracterización química y toxicológica permite definir límites aceptables y estrategias de purificación.
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