Impureza dímero de dapagliflozina presente como subproducto de síntesis o degradación | caracterizada por masa molecular doble y perfil cromatográfico distintivo. Esta impureza exige monitoreo riguroso en control de calidad mediante métodos analíticos validados como HPLC con detección UV y espectrometría de masas para confirmar estructura y cuantificar niveles. Se evalúan parámetros de retención | fragmentación y límites de detección y cuantificación para garantizar cumplimiento con especificaciones internas y guías regulatorias ICH sobre impurezas. La identificación temprana y el establecimiento de límites de aceptación facilitan la gestión de riesgos en el proceso y la optimización de pasos sintéticos para minimizar formación de dímeros.
Referencias
Anderson, S. L. (2014). Dapagliflozin efficacy and safety: a perspective review. Therapeutic Advances in Drug Safety, 5(6), 242–254. https://doi.org/10.1177/2042098614551938 ‌
Solicitar cotización
"*" señala los campos obligatorios
Otros productos relacionados con Dapagliflozin impurities
To provide the best experiences, we use technologies like cookies to store and/or access device information. Consenting to these technologies will allow us to process data such as browsing behavior or unique IDs on this site. Not consenting or withdrawing consent, may adversely affect certain features and functions.
Functional
Siempre activo
The technical storage or access is strictly necessary for the legitimate purpose of enabling the use of a specific service explicitly requested by the subscriber or user, or for the sole purpose of carrying out the transmission of a communication over an electronic communications network.
Preferences
The technical storage or access is necessary for the legitimate purpose of storing preferences that are not requested by the subscriber or user.
Statistics
The technical storage or access that is used exclusively for statistical purposes.The technical storage or access that is used exclusively for anonymous statistical purposes. Without a subpoena, voluntary compliance on the part of your Internet Service Provider, or additional records from a third party, information stored or retrieved for this purpose alone cannot usually be used to identify you.
Marketing
The technical storage or access is required to create user profiles to send advertising, or to track the user on a website or across several websites for similar marketing purposes.
To provide the best experiences, we use technologies like cookies to store and/or access device information. Consenting to these technologies will allow us to process data such as browsing behavior or unique IDs on this site. Not consenting or withdrawing consent, may adversely affect certain features and functions.
Functional
Siempre activo
The technical storage or access is strictly necessary for the legitimate purpose of enabling the use of a specific service explicitly requested by the subscriber or user, or for the sole purpose of carrying out the transmission of a communication over an electronic communications network.
Preferences
The technical storage or access is necessary for the legitimate purpose of storing preferences that are not requested by the subscriber or user.
Statistics
The technical storage or access that is used exclusively for statistical purposes.The technical storage or access that is used exclusively for anonymous statistical purposes. Without a subpoena, voluntary compliance on the part of your Internet Service Provider, or additional records from a third party, information stored or retrieved for this purpose alone cannot usually be used to identify you.
Marketing
The technical storage or access is required to create user profiles to send advertising, or to track the user on a website or across several websites for similar marketing purposes.
