Dapagliflozin Impurity 15, también denominada Dapagliflozin Despyranose Bromo Impurity, CAS 461432-23-5, es una impureza halogenada de proceso asociada con la modificación estructural del esqueleto de dapagliflozina por pérdida del motivo piranósido e incorporación de bromo. Presenta fórmula molecular C15H14BrClO y masa molecular de 325.63 g/mol, lo que sugiere un éter aromático lipófilo con carácter de haluro. Su formación suele relacionarse con arrastre de intermedios sintéticos o reacciones secundarias de halogenación durante la fabricación. Para su identificación y cuantificación se requieren habitualmente LC-MS/MS, LC-HRMS y HPLC ortogonal con detección UV o CAD.
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