El etilenglicol, CAS 107-21-1, es un diol alifático de bajo peso molecular con fórmula C2H6O2 y peso molecular de 62,07 g/mol. Como solvente hidrofílico y fuertemente enlazado por puentes de hidrógeno, y como humectante, suele aparecer como impureza de proceso o reactivo residual en operaciones de síntesis y purificación multietapa. Aunque no se clasifica como impureza genotóxica según ICH M7, su relevancia toxicológica deriva de la exposición sistémica y de efectos renales dependientes de la dosis. La determinación precisa suele requerir GC-MS en modo headspace o directo, a menudo con derivatización, o LC-MS/MS cuando la complejidad de la matriz limita la medición por volatilidad.
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