La impureza A de pantoprazol EP, también denominada impureza A de pantoprazol BP, compuesto relacionado A de pantoprazol y sulfona de pantoprazol, es el producto de degradación oxidativa en la serie sulfona, no una especie de nitrosamina. El CAS 127780-16-9 identifica esta impureza benzimidazólica, con fórmula molecular C16H15F2N3O5S y peso molecular de 399.37 g/mol. Su formación suele relacionarse con estrés oxidativo durante la síntesis, el almacenamiento o la exposición a excipientes con peróxidos. Dada la posible coelución de especies sulfoxido y sulfona, su caracterización exige habitualmente LC-MS/MS ortogonal, HPLC con detección por arreglo de diodos y, cuando procede, espectrometría de masas de alta resolución.
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