4-Chloro-3-sulfamoylbenzoic acid, CAS 1205-30-7, is an aromatic sulfonamide benzoic acid impurity with formula C7H6ClNO4S and molecular weight 235.64 g/mol. The ortho relationship of the carboxylic acid and sulfonamide functions, together with the para-chloro substituent, defines a polar, weakly acidic analyte relevant to process-related impurity profiling and degradation studies of chlorinated sulfonamide intermediates. Its occurrence may arise from incomplete sulfonation or chlorination sequence control during synthesis. Trace-level determination generally requires LC-MS/MS, high-resolution LC-MS, or ion-pair LC with UV confirmation, because conventional HPLC alone may not resolve structurally related aromatic acids.
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