Cefdinir Decarboxy Open Ring Lactone (CAS 178949-04-7) is a structurally related degradation impurity of the third-generation cephalosporin cefdinir, arising from β-lactam ring opening followed by decarboxylative rearrangement and lactonization. With molecular formula C13H15N5O4S2 and molecular weight 369.42 g/mol, it retains the dihydrothiazine sulfur motif while lacking the intact cephem pharmacophore. The transformation is consistent with hydrolytic and stress-induced pathways during storage or processing. Due to its polar, nonvolatile character, characterization generally requires LC-MS/MS, high-resolution LC-MS, and impurity profiling by reversed-phase HPLC with diode-array or MS detection. It is not a nitrosamine, but its presence is relevant to stability-indicating control strategies.
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