Dapagliflozin EP Impurity B, also designated Dapagliflozin Impurity 27 and Ethyl Dapagliflozin, is a structurally related ether analog of the SGLT2 inhibitor dapagliflozin, corresponding to alkylation at the phenolic oxygen by an ethyl substituent. This process-related impurity, CAS 3093141-55-7, has molecular formula C23H29ClO6 and molecular weight 436.9 g/mol. Its presence is typically associated with synthetic side-reactions or incomplete dealkylation control during route development. Because of close chromatographic and mass spectrometric similarity to the parent drug, characterization commonly requires LC-MS/MS, high-resolution mass spectrometry, and orthogonal HPLC separations for definitive assignment and quantification.
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