Dapagliflozin Inhouse Impurity B / Dapagliflozin Impurity 57, CAS 1662702-90-0, is the aryl ether benzyl chloride intermediate 1-[(2-chlorophenyl)methyl]-4-ethoxybenzene, formula C15H15ClO, molecular weight 246.73 g/mol. It is structurally related to nonpolar chlorobenzyl ether process impurities rather than to a reactive genotoxic class. Such species commonly arise from incomplete benzylation, etherification side reactions, or carryover of chlorobenzyl starting materials during synthesis of dapagliflozin intermediates. Characterization typically requires LC-MS, GC-MS, and NMR, with GC-MS especially useful because of its volatility and aromatic hydrophobicity. Regulatory relevance lies in impurity profiling and control of synthesis-derived organochlorine residues.
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