Ethyl arachidate, also known as ethyl icosanoate, CAS 18281-05-5, is the ethyl ester of arachidic acid and a long-chain saturated fatty acid ester with formula C22H44O2 and molecular weight 340.58 g/mol. In pharmaceutical impurity profiling, it is usually considered a process-related esterification byproduct or adventitious lipid-derived contaminant rather than a reactive mutagenic species. Its low polarity and high hydrophobicity favor retention on reversed-phase systems, while definitive identification commonly relies on GC-MS, GC-FID, or LC-MS/MS after suitable chromatographic resolution. Quantification may require elevated temperatures or derivatization strategies because of limited volatility and strong matrix partitioning.
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