Norfloxacin EP Impurity G
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70459-04-0Norfloxacin EP Impurity G

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Catalogue No.:VL3030005
CAS No.:70459-04-0
Mol. Formula:C17H18FN3O4
Mol. Weight:347.34 g/mol

Additional information on CAS 70459-04-0

Parent drug

Norfloxacin

IUPAC Name

1-Ethyl-6-fluoro-7-(4-formylpiperazin-1-yl)-4-oxo-1, 4-dihydroquinoline-3-carboxylic acid

Pharmacopoeial Synonyms

N/A

Other Synonyms

Norfloxacin N-Formyl Impurity;7-(4-formylpiperazin-1-yl)-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

Smile

O=C(C1=CN(CC)C2=C(C=C(F)C(N3CCN(C=O)CC3)=C2)C1=O)O

Inchl

InChI=1S/C17H18FN3O4/c1-2-20-9-12(17(24)25)16(23)11-7-13(18)15(8-14(11)20)21-5-3-19(10-22)4-6-21/h7-10H,2-6H2,1H3,(H,24,25)

Description

Norfloxacin EP Impurity G is a meticulously characterized reference material that complies with rigorous regulatory requirements, including those defined by USP, EMA, JP, and BP. This product plays a crucial role in Abbreviated New Drug Applications (ANDA), New Drug Applications (NDA), and the commercial manufacturing of Norfloxacin. It is further supported by a detailed Structure Elucidation Report (SER), ensuring high accuracy and reliability across a broad range of analytical applications. Norfloxacin EP Impurity G (CAS No: 70459-04-0) or Norfloxacin N-Formyl Impurity is an impurity present in the synthesis of Norfloxacin which s most often used for the medication of rectal and pharyngeal gonococcal infections, has been identified as the main products of its photodegradation.

References

Mielji, Branislava, et al. “Column High-Performance Liquid Chromatographic Determination of Norfloxacin and Its Main Impurities in Pharmaceuticals.” Journal of AOAC INTERNATIONAL, vol. 91, no. 2, Mar. 2008, pp. 332–38, https://doi.org/10.1093/jaoac/91.2.332.?Kaplowitz, Lisa G., et al. “Norfloxacin in the Treatment of Uncomplicated Gonococcal Infections.” The American Journal of Medicine, vol. 82, no. 6, June 1987, pp. 35–39, https://doi.org/10.1016/0002-9343(87)90616-4.?

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