1012341-50-2: (2R,4S)-5-(Biphenyl-4-yl)-4-[(tert-butoxycarbonyl)amino]-2-methylpentanoic Acid
It is one of impurity present in Sacubitril, Sacubitril is a prodrug neprilysin inhibitor and is a neutral endopeptidase that would typically cleave natriuretic peptides, which includes atrial natriuretic peptide, brain natriuretic peptide, and c-type natriuretic peptide. they are released under atrial and ventricle stress, which activate downstream receptors leading to vasodilation, natriuresis, and diuresis. endothelin-1 and peptide amyloid beta-protein. Inhibition of neprilysin reduced breakdown and increased concentration of endogenous natriuretic peptides in addition to increased levels of vasoconstricting hormones such as angiotensin II, which reduce the risk of cardiovascular death and heart failure.
Additional information on CAS 1012341-50-2
(2R, 4S)-5-biphenyl-4-yl-4-tert-butoxycarbonylamino-2-methylpentanoic acid
Kaplinsky, E. (2016). Sacubitril/valsartan in heart failure: latest evidence and place in therapy. Therapeutic Advances in Chronic Disease, 7(6), 278–290. https://doi.org/10.1177/2040622316665350
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