1322062-76-9: Lacosamide EP Impurity D (HCl salt)
Also known as Lacosamide N-Desacetyl Impurity (HCl salt), it is one impurity present in Lacosamide, Lacosamide may be selective for inhibiting depolarized neurons rather than neurons with normal resting potentials. Pain and nociceptor hyperexcitability are associated with neural membrane depolarization. Lacosamide binds to collapsin response mediator protein-2, a phosphoprotein that is expressed primarily in the nervous system and is involved in neuronal differentiation and control of axonal outgrowth. The role of CRMP-2 of binding in seizure control, which is used to treat partial onset seizures.
Additional information on CAS 1322062-76-9
VE009203
1322062-76-9
C11H17ClN2O2
244.72 g/mol
Lacosamide
(2E)-2-amino-N-benzyl-3-methoxypropanamide hydrochloride
Lacosamide N-Desacetyl Impurity (HCl salt)
Abou-Khalil, B. W. (2009). Lacosamide: What Can be Expected from the Next New Antiepileptic Drug? Epilepsy Currents, 9(5), 133–134. https://doi.org/10.1111/j.1535-7511.2009.01317.x
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