136401-69-9: Pioglitazone EP Impurity B

Also known as Didehydro Pioglitazone Impurity, it is one of impurity present in Pioglitazone, Pioglitazone is a selective agonist at peroxisome proliferator, activated receptor-gamma in target tissues for insulin action such as adipose tissue, skeletal muscle, and liver, PPARγ increases the transcription of insulin-responsive genes. pioglitazone both enhances tissue sensitivity to insulin and reduces the hepatic production of glucose-insulin resistance associated with type 2 diabetes mellitus is improved without an increase in insulin secretion by pancreatic beta cells.