It is a fluorinated analog of natural hydrophobic amino acids. It is one of the most hydrophobic amino acids that are important to gain efficient packing within the hydrophobic core.
References
Salwiczek, Mario. “Biophysical Aspects of Single Fluoroalkylamino Acid Substitutions within a Natural Polypeptide Environment.†Fu-Berlin.de, June 2010, https://refubium.fu-berlin.de/handle/fub188/11230.
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