346451-15-8: Cetirizine EP Impurity D
Also known as Dimer Impurity or 1,4-Bis[(4-chlorophenyl)phenylmethyl]piperazine (free Base), it is one of impurity present in Cetirizine, Cetirizine is the active metabolite of the piperazine H1-receptor antagonist hydroxyzine. Cetirizine is a metabolite of hydroxyzine an antihistamine drug. Its effects are achieved through selective inhibition of peripheral H1 receptors. which eliminates the symptoms of chronic idiopathic urticaria, perennial allergic rhinitis, seasonal allergic rhinitis, allergic asthma, physical urticaria, and atopic dermatitis.
Additional information on CAS 346451-15-8
Dimer Impurity / 1,4-Bis[(4-chlorophenyl)phenylmethyl]piperazine (free Base)
Naqvi, A., & Gerriets, V. (2022, May 19). Cetirizine. Retrieved October 31, 2022, from Nih.gov website: https://www.ncbi.nlm.nih.gov/books/NBK549776/
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