94266-17-8: Xylometazoline EP Impurity A
It is an impurity present in Xylometazoline, Xylometazoline is an imidazoline derivative, and Xylometazoline is a selective agonist at α2B-adrenoceptors. Nasal congestion is caused by various etiologies such as rhinosinusitis and allergies. Activation of α-adrenergic receptors leads to vasoconstriction of the blood vessels of the nasal mucosa and resumption of nasal airflow. Xylometazoline decreases nasal resistance during inspiration and expiration and increases the volume of nasal airflow, which is used for the symptomatic treatment of nasal congestion and minor inflammation due to allergies or colds. xylometazoline also exerts anti-oxidant actions it inhibited microsomal lipid peroxidation and mediated hydroxyl radical scavenging activity.
Additional information on CAS 94266-17-8
N-(2-Aminoethyl)-2-[4-(1, 1-dimethylethyl)-2, 6-dimethylphenyl]acetamide
Graf, C., Bernkop-Schnürch, A., Egyed, A., Koller, C., Prieschl-Grassauer, E., & Morokutti-Kurz, M. (2018). Development of a nasal spray containing xylometazoline hydrochloride and iota-carrageenan for the symptomatic relief of nasal congestion caused by rhinitis and sinusitis. International Journal of General Medicine, Volume 11, 275–283. https://doi.org/10.2147/ijgm.s167123