141271-12-7: Abacavir Related Compound B

141271-12-7: Abacavir Related Compound B

Abacavir Related Compound B (CAS No: 141271-12-7) is an impurity of Abacavir that is a carbocyclic 2?-deoxyguanosine nucleoside analog. The mechanism includes its conversion intracellularly to a 2?-deoxyguanosine nucleoside analog that competitively restrains HIV reverse transcriptase and eliminates proviral DNA chain extension.

Additional information on CAS 141271-12-7

Catalogue No.

VL760025
CAS No.

141271-12-7
Molecular Formula

C10H14ClN5O
Molecular Weight

255.7
Parent drug

Abacavir
IUPAC Name

(4-((2, 5-diamino-6-chloropyrimidin-4-yl)amino)cyclopent-2-en-1-yl)methanol
Synonyms

N/A
References

Hervey, Pauline S., and Caroline M. Perry. “Abacavir.” Drugs, vol. 60, no. 2, Aug. 2000, pp. 447–79, https://doi.org/10.2165/00003495-200060020-00015. Jain, Mohit, et al. “A Simple and Sensitive Method for the Ultra Trace Determination of Potential Genotoxic Impurities in Abacavir Sulfate by LC-MS.” Chemical Methodologies, vol. 2, no. 4, Sami Publishing Company, Oct. 2018, pp. 315–23, https://doi.org/10.22034/chemm.2018.66185.
Status

Under Development

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141271-12-7: Abacavir Related Compound B

141271-12-7: Abacavir Related Compound B
Catalogue No.

VL760025
CAS No.

141271-12-7
Molecular Formula

C10H14ClN5O
Molecular Weight

255.7
Parent drug

Abacavir
IUPAC Name

(4-((2, 5-diamino-6-chloropyrimidin-4-yl)amino)cyclopent-2-en-1-yl)methanol
Synonyms

N/A
References

Hervey, Pauline S., and Caroline M. Perry. “Abacavir.” Drugs, vol. 60, no. 2, Aug. 2000, pp. 447–79, https://doi.org/10.2165/00003495-200060020-00015. Jain, Mohit, et al. “A Simple and Sensitive Method for the Ultra Trace Determination of Potential Genotoxic Impurities in Abacavir Sulfate by LC-MS.” Chemical Methodologies, vol. 2, no. 4, Sami Publishing Company, Oct. 2018, pp. 315–23, https://doi.org/10.22034/chemm.2018.66185.
Status

Under Development
ListName

Abacavir Related Compound B
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