141271-12-7: Abacavir Related Compound B
Abacavir Related Compound B (CAS No: 141271-12-7) is an impurity of Abacavir that is a carbocyclic 2?-deoxyguanosine nucleoside analog. The mechanism includes its conversion intracellularly to a 2?-deoxyguanosine nucleoside analog that competitively restrains HIV reverse transcriptase and eliminates proviral DNA chain extension.
Additional information on CAS 141271-12-7
Hervey, Pauline S., and Caroline M. Perry. “Abacavir.” Drugs, vol. 60, no. 2, Aug. 2000, pp. 447–79, https://doi.org/10.2165/00003495-200060020-00015. Jain, Mohit, et al. “A Simple and Sensitive Method for the Ultra Trace Determination of Potential Genotoxic Impurities in Abacavir Sulfate by LC-MS.” Chemical Methodologies, vol. 2, no. 4, Sami Publishing Company, Oct. 2018, pp. 315–23, https://doi.org/10.22034/chemm.2018.66185.
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