141271-12-7: Abacavir Related Compound B

Status: Under Development

Abacavir Related Compound B (CAS No: 141271-12-7) is an impurity of Abacavir that is a carbocyclic 2?-deoxyguanosine nucleoside analog. The mechanism includes its conversion intracellularly to a 2?-deoxyguanosine nucleoside analog that competitively restrains HIV reverse transcriptase and eliminates proviral DNA chain extension.

Additional information on CAS 141271-12-7

Catalogue No. VL760025
CAS No. 141271-12-7
Molecular Formula C10H14ClN5O
Molecular Weight 255.7 g/mol
Parent drug Abacavir
IUPAC Name (4-((2, 5-diamino-6-chloropyrimidin-4-yl)amino)cyclopent-2-en-1-yl)methanol
Synonyms N/A
References Hervey, Pauline S., and Caroline M. Perry. “Abacavir.” Drugs, vol. 60, no. 2, Aug. 2000, pp. 447–79, https://doi.org/10.2165/00003495-200060020-00015. Jain, Mohit, et al. “A Simple and Sensitive Method for the Ultra Trace Determination of Potential Genotoxic Impurities in Abacavir Sulfate by LC-MS.” Chemical Methodologies, vol. 2, no. 4, Sami Publishing Company, Oct. 2018, pp. 315–23, https://doi.org/10.22034/chemm.2018.66185.
Status Under Development

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