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2378463-76-2Abiraterone N-Oxide Impurity

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Catalogue No.:	VL830002
CAS No.:	2378463-76-2
Mol. Formula:	C24H31NO2
Mol. Weight:	365.51 g/mol

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Additional information on CAS 2378463-76-2

Parent drug

Abiraterone

IUPAC Name

3-((3S, 8R, 9S, 10R, 13S, 14S)-3-hydroxy-10, 13-dimethyl-2, 3, 4, 7, 8, 9, 10, 11, 12, 13, 14, 15-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl)pyridine 1-oxide

Pharmacopoeial Synonyms

N/A

Other Synonyms

N/A

Smiles

C[C@@]12C(C3=C[N+]([O-])=CC=C3)=CC[C@@]1([H])[C@]4([H])CC=C5C[C@@H](O)CC[C@]5(C)[C@@]4([H])CC2

Inchl

InChI=1S/C24H31NO2/c1-23-11-9-18(26)14-17(23)5-6-19-21-8-7-20(16-4-3-13-25(27)15-16)24(21,2)12-10-22(19)23/h3-5,7,13,15,18-19,21-22,26H,6,8-12,14H2,1-2H3/t18-,19-,21-,22-,23-,24+/m0/s1

Description

Abiraterone N-Oxide Impurity is an impurity of Abiraterone acetate, a prodrug used in the treatment of castration-resistant prostate cancer. It acts by converting itself in vivo to abiraterone which inhibits androgen biosynthesis. It induces cancerous tissue as well as the natural production of androgens.

References

Mach, Samuel, et al. â€œEpoxidation Is the Preferred Pathway of First-Stage Metabolism of Abiraterone Acetate in Brown Bullhead (Ameiurus Nebulosus).â€ Environmental Science and Pollution Research, vol. 26, no. 34, Oct. 2019, pp. 34896â€“904, https://doi.org/10.1007/s11356-019-06568-y.