63181-13-5: Alfacalcidol EP Impurity B
Alfacalcidol EP Impurity B or 1v-Calcidol/(5Z,7E)-9,10-Secocholesta-5,7,10(19)-triene-1ß,3ß-diol is an inactive isomeric impurity of Alphacalcidol is a glucocorticoid used in patients with rheumatic diseases and are associated with increased bone loss and risk of fracture.
Additional information on CAS 63181-13-5
VL5740003
63181-13-5
C27H44O2
400.64 g/mol
Alfacalcidol
6ξ-[(3S,5R)-3,5-dihydroxy-2-methylcyclohex-1-en-1-yl]-2-phenyl-2,5,10-triaza-17β-[(2R)-6-methylheptan-2-yl]-4-nor-9ξ-estr-7-ene-1,3-dione
1β-Calcidol
Holick, M. F., et al. “1a-Hydroxy Derivative of Vitamin D 3 : A Highly Potent Analog of 1a, 25-Dihydroxyvitamin D 3.” Science, vol. 180, no. 4082, Apr. 1973, pp. 190–91, https://doi.org/10.1126/science.180.4082.190. de Nijs, Ron N. J., et al. “Alendronate or Alfacalcidol in Glucocorticoid-Induced Osteoporosis.” New England Journal of Medicine, vol. 355, no. 7, Aug. 2006, pp. 675–84, https://doi.org/10.1056/nejmoa053569.
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