1106685-84-0: Ambrisentan 4-Hydroxymethyl Analog Racemate
Ambrisentan 4-Hydroxymethyl Analog Racemate (CAS No: 1106685-84-0) or rac 4-Hydroxymethyl Ambrisentan chemically known as 2-[(6-Methyl-4-hydroxymethyl-pyrimidine-2-yl)oxy]-3-methoxy-3,3-diphenyl propanoic acid is a metabolite formed in Ambrisentan, which is employed in the therapy of Pulmonary Arterial Hypertension.
Additional information on CAS 1106685-84-0
rac 4-Hydroxymethyl Ambrisentan ; 2-[(6-Methyl-4-hydroxymethyl-pyrimidin-2-yl)oxy]-3-methoxy-3, 3-diphenyl propanoic acid
Johnsi Rani, P., et al. “Metabolite Characterization of Ambrisentan, in in Vitro and in Vivo Matrices by UHPLC/QTOF/MS/MS: Detection of Glutathione Conjugate of Epoxide Metabolite Evidenced by in Vitro GSH Trapping Assay.” Journal of Pharmaceutical and Biomedical Analysis, vol. 155, June 2018, pp. 320–28, https://doi.org/10.1016/j.jpba.2018.04.013.?
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