1384439-80-8: Apremilast Impurity 11

Apremilast Impurity 11 (CAS NO.-1384439-80-8) IUPAC Name-4-Amino-2-[(1S)-1-(3 ,4-dihydroxyphenyl)-2-(methylsulfonyl)ethyl]-1H-isoindole-1,3(2H)-dione. Apremilast is an oral phosphodiesterase 4 inhibitor that has an impact on a wide range of inflammatory mediators involved in psoriasis and psoriatic arthritis, this is a novel treatment that focuses on maintaining a balance between pro-inflammatory and anti-inflammatory signals.

Additional information

Catalogue No.

VE008021

CAS No.

1384439-80-8

Molecular Formula

C17H16N2O6S

Molecular Weight

376.38 g/mol

IUPAC Name

4-Amino-2-[(1S)-1-(3, 4-dihydroxyphenyl)-2-(methylsulfonyl)ethyl]-1H-isoindole-1, 3(2H)-dione

Synonyms

Apremilast N-Desacetyl O4-Desmethyl O3-Desethyl Impurity

References

Schafer, Peter. “Apremilast Mechanism of Action and Application to Psoriasis and Psoriatic Arthritis.” Biochemical Pharmacology, vol. 83, no. 12, June 2012, pp. 1583–90, https://doi.org/10.1016/j.bcp.2012.01.001.

Status

In-stock