Apremilast Impurity 8 (CAS NO.-2096492-44-1) IUPAC Name-(S)-N-(2-(1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-7-hydroxy-1,3-dioxoisoindolin-4-yl)acetamide. Apremilast is an oral phosphodiesterase 4 inhibitors that have an impact on a wide range of inflammatory mediators involved in psoriasis and psoriatic arthritis, this is the novel treatment that focuses on maintaining a balance between pro-inflammatory and anti-inflammatory signals.
References
Schafer, Peter. “Apremilast Mechanism of Action and Application to Psoriasis and Psoriatic Arthritis.†Biochemical Pharmacology, vol. 83, no. 12, June 2012, pp. 1583–90, https://doi.org/10.1016/j.bcp.2012.01.001.
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