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29122-74-5Bisoprolol EP Impurity L

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Catalogue No.:	VL191001
CAS No.:	29122-74-5
Mol. Formula:	C13H19NO3
Mol. Weight:	237.29 g/mol

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Additional information on CAS 29122-74-5

Parent drug

Bisoprolol /Metoprolol

IUPAC Name

4-[((2RS)-2-Hydroxy-3-(isopropylamino)-propyl)oxy]benzaldehyde

Pharmacopoeial Synonyms

Metoprolol EP Impurity C; Metoprolol Related Compound C

Other Synonyms

N/A

Smiles

O=CC1=CC=C(OCC(O)CNC(C)C)C=C1

InChI

InChI=1S/C13H19NO3/c1-10(2)14-7-12(16)9-17-13-5-3-11(8-15)4-6-13/h3-6,8,10,12,14,16H,7,9H2,1-2H3

Description

Metoprolol EP Impurity C, also designated Metoprolol Related Compound C and Bisoprolol EP Impurity L (free base), CAS 29122-74-5, is a defined structural impurity with molecular formula C13H19NO3 and molecular weight 237.29 g/mol. The compound is a beta-amino alcohol ether of the aryloxypropanolamine class, consistent with process-related formation through incomplete etherification, regioisomeric synthesis, or hydrolytic transformation of related beta-blockers. Its separation often requires reversed-phase LC coupled to UV and confirmation by LC-MS/MS, with NMR used for structural assignment and impurity profiling. Regulatory evaluation focuses on related-substance control rather than ICH M7 genotoxic concern.